Discovery of new genetic loci for male sexual orientation in Han population.

ABSTRACT: Epidemiological studies have demonstrated that the genetic factors partly influence the development of same-sex sexual behavior, but most genetic studies have focused on people of primarily European ancestry, potentially missing important biological insights. Here, we performed a two-stage genome-wide association study (GWAS) with a total sample of 1478 homosexual males and 3313 heterosexual males in Han Chinese populations and identified two genetic loci (rs17320865, Xq27.3, FMR1NB, P_meta = 8.36 × 10^-8, OR = 1.29; rs7259428, 19q12, ZNF536, P_meta = 7.58 × 10^-8, OR = 0.75) showing consistent association with male sexual orientation. A fixed-effect meta-analysis including individuals of Han Chinese (n = 4791) and European ancestries (n = 408,995) r

SUBMITTER: Hu SH 

PROVIDER: S-EPMC8558329 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature