Comparing Genetic and Socioenvironmental Contributions to Ethnic Differences in C-Reactive Protein.

ABSTRACT: C-reactive protein (CRP) is a routinely measured blood biomarker for inflammation. Elevated levels of circulating CRP are associated with response to infection, risk for a number of complex common diseases, and psychosocial stress. The objective of this study was to compare the contributions of genetic ancestry, socioenvironmental factors, and inflammation-related health conditions to ethnic differences in C-reactive protein levels. We used multivariable regression to compare CRP blood serum levels between Black and White ethnic groups from the United Kingdom Biobank (UKBB) prospective cohort study. CRP serum levels are significantly associated with ethnicity in an age and sex adjusted model. Study participants who identify as Black have higher average CRP than those who identify as White,

SUBMITTER: Nagar SD 

PROVIDER: S-EPMC8558394 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature