Local Progression Kinetics of Geographic Atrophy Depends Upon the Border Location.

ABSTRACT:

Purpose

To assess the influence of lesion morphology and location on geographic atrophy (GA) growth rate.

Methods

We manually delineated GA on color fundus photographs of 237 eyes in the Age-Related Eye Disease Study. We calculated local border expansion rate (BER) as the linear distance that a point on the GA border traveled over 1 year based on a Euclidean distance map. Eye-specific BER was defined as the mean local BER of all points on the GA border in an eye. The percentage area affected by GA was defined as the GA area divided by the total retinal area in the region.

Results

GA enlarged 1.51 ± 1.96 mm2 in area and 0.13 ± 0.11 mm in distance over 1 year. The GA area growth rate (mm2/y) was associated with the baseline GA area (P < 0.001), perimeter (P < 0.001), le

SUBMITTER: Shen LL 

PROVIDER: S-EPMC8558522 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature