Clinical and Preclinical Outcomes of Combining Targeted Therapy With Radiotherapy.

ABSTRACT: In the era of precision medicine, radiation medicine is currently focused on the precise delivery of highly conformal radiation treatments. However, the tremendous developments in targeted therapy are yet to fulfill their full promise and arguably have the potential to dramatically enhance the radiation therapeutic ratio. The increased ability to molecularly profile tumors both at diagnosis and at relapse and the co-incident progress in the field of radiogenomics could potentially pave the way for a more personalized approach to radiation treatment in contrast to the current ''one size fits all'' paradigm. Few clinical trials to date have shown an improved clinical outcome when combining targeted agents with radiation therapy, however, most have failed to show benefit, which is arguably du

SUBMITTER: Elbanna M 

PROVIDER: S-EPMC8558533 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature