Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals.

ABSTRACT:

Background

Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X chromosome is inactive. Moreover, the inactive X chromosome is reactivated during development in the inner cell mass and in germ cells through X chromosome reactivation, which can be studied in vitro by reprogramming of somatic cells to pluripotency. How chromatin processes and gene regulatory networks evolved to regulate X chromosome dosage in the somatic state and during X chromosome reactivation remains unclear.

Results

Using genome-wide approaches, allele-specific ATAC-seq and single-cell RNA-seq, in female embryonic fibroblasts a

SUBMITTER: Talon I 

PROVIDER: S-EPMC8558763 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature