Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC8558802 | biostudies-literature | 2021 Jan-Dec
REPOSITORIES: biostudies-literature
Wang Le L Ren Bingcheng B Zhuang Hao H Zhong Yue Y Nan Yang Y
Technology in cancer research & treatment 20210101
Glioma is the most common primary intracranial tumor. Abnormal expression of CBX2 (ChromoBox2) is associated with tumorigenesis and tumor development. TCGA data in UALCAN showed that CBX2 was overexpressed in glioma tissue. To confirm the role of CBX2 in glioma, we regulated the level of CBX2 and conducted colony formation, Transwell, and CCK-8 assays to verify the effect of CBX2. The results showed that CBX2 knockdown reduced glioma cell proliferation and invasion and that the cells were less t ...[more]