Anterior cingulate cortex activity during attentional control corresponds with rumination in depression and social anxiety.

ABSTRACT: Rumination and worry are transdiagnostic perseverative cognitions that have overlapping and distinct characteristics. While the mechanisms of perseverative cognitions remain incomplete, limited data indicate anterior cingulate cortex (ACC) as it relates to top-down functions contributes to perseverative cognitions in internalizing conditions. The current study extends this work in patients with major depression (n = 39) or social anxiety (n = 42). During fMRI, participants viewed images comprising letter strings superimposed on task-irrelevant threatening or neutral faces. To moderate task difficulty, there was a low perceptual load condition where the target letter was in a string of identical letters and high load condition with the target letter in a mixed letter string increasing task

SUBMITTER: Sheena MK 

PROVIDER: S-EPMC8559256 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature