Capacity Building for Primary Stroke Prevention Teams in Children Living With Sickle Cell Anemia in Africa.

ABSTRACT:

Background

Nigeria has the highest proportion of children with sickle cell anemia (SCA) globally; an estimated 150,000 infants with SCA are born annually. Primary stroke prevention in children with SCA must include Nigeria. We describe capacity-building strategies in conjunction with two National Institutes of Health-funded primary stroke prevention trials (a feasibility trial and phase III randomized controlled trial) with initial hydroxyurea treatment for children with SCA and abnormal transcranial Doppler (TCD) velocities in Nigeria. We anticipated challenges to conducting clinical trials in a low-resource setting with a local team that had not previously been involved in clinical research and sought a sustainable strategy for primary stroke prevention.

Methods

This is a

SUBMITTER: Ghafuri DL 

PROVIDER: S-EPMC8559257 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature