Role of Oxidative Stress and Autophagy in Thoracic Aortic Aneurysms.
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ABSTRACT:
SUBMITTER: Irace FG
PROVIDER: S-EPMC8559314 | biostudies-literature | 2021 Sep-Oct
REPOSITORIES: biostudies-literature
Publications
Role of Oxidative Stress and Autophagy in Thoracic Aortic Aneurysms.
Irace Francesco G FG Cammisotto Vittoria V Valenti Valentina V Forte Maurizio M Schirone Leonardo L Bartimoccia Simona S Iaccarino Alessandra A Peruzzi Mariangela M Schiavon Sonia S Morelli Andrea A Marullo Antonino G M AGM Miraldi Fabio F Nocella Cristina C De Paulis Ruggero R Benedetto Umberto U Greco Ernesto E Biondi-Zoccai Giuseppe G Sciarretta Sebastiano S Carnevale Roberto R Frati Giacomo G
JACC. Basic to translational science 20210901 9-10
Thoracic aortic aneurysms (TAA) pathogenesis and progression include many mechanisms. The authors investigated the role of autophagy, oxidative stress, and endothelial dysfunction in 36 TAA patients and 23 control patients. Univariable and multivariable analyses were performed. TAA patients displayed higher oxidative stress and endothelial dysfunction then control patients. Autophagy in the TAA group was reduced. The association of oxidative stress and autophagy with aortic disease supports the ...[more]
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