Leptospirosis infections among hospital patients, Sarawak, Malaysia.

ABSTRACT:

Background

Leptospirosis diagnoses have increased in Sarawak, Malaysia in recent years.

Methods

To better understand the burden of disease and associated risk factors, we evaluated 147 patients presenting with clinical leptospirosis to local hospitals in Sarawak, Malaysia for the presence of Leptospira and associated antibodies. Sera and urine specimens collected during the acute illness phase were assessed via a commercially available rapid diagnostic test (Leptorapide, Linnodee Ltd., Antrim, Northern Ireland), an ELISA IgM assay (Leptospira IgM ELISA, PanBio, Queensland, Australia) and a pan-Leptospira real-time PCR (qPCR) assay to estimate disease prevalence and diagnostic accuracy of each method. Microagglutination testing was performed on a subset of samples.

Results

SUBMITTER: Hii KC 

PROVIDER: S-EPMC8559352 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature