The obesity paradox and hypoglycemia in critically ill patients.

ABSTRACT:

Background

A high body mass index (BMI) has been associated with decreased mortality in critically ill patients. This association may, in part, relate to the impact of BMI on glycemia. We aimed to study the relationship between BMI, glycemia and hospital mortality.

Methods

We included all patients with a recorded BMI from four large international clinical databases (n = 259,177). We investigated the unadjusted association of BMI with average glucose levels, mortality and hypoglycemia rate. We applied multivariate analysis to investigate the impact of BMI on hypoglycemia rate, after adjusting for glycemia-relevant treatments (insulin, dextrose, corticosteroids, enteral and parenteral nutrition) and key physiological parameters (previous blood glucose level, blood lactate, sho

SUBMITTER: Plecko D 

PROVIDER: S-EPMC8559391 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature