Incorporating genetic and clinical data into the prediction of thromboembolism risk in patients with lymphoma.

ABSTRACT:

Background

The incorporation of genetic variables into risk scores for predicting venous thromboembolic events (VTE) could improve their capacity to identify those patients for whom thromboprophylaxis would be most beneficial. Proof-of-concept of this is provided by the TiC-ONCO score for predicting the risk of VTE in patients with solid tumours. Our aim was to develop a similarly improved tool-the TiC-LYMPHO score-for predicting VTE in patients with lymphoma.

Methods

In a retrospective observational study of 208 patients with lymphoma, 31 (14.9%) were found to have experienced an episode of VTE either at the time of diagnosis or over the next 6 months. Clinical variables associated with VTE, determined via logistic regression analysis, plus the same genetic variables includ

SUBMITTER: Bastos-Oreiro M 

PROVIDER: S-EPMC8559493 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature