Maternal Iron Deficiency Alters Trophoblast Differentiation and Placental Development in Rat Pregnancy.

ABSTRACT: Iron deficiency, which occurs when iron demands chronically exceed intake, is prevalent in pregnant women. Iron deficiency during pregnancy poses major risks for the baby, including fetal growth restriction and long-term health complications. The placenta serves as the interface between a pregnant mother and her baby, and it ensures adequate nutrient provisions for the fetus. Thus, maternal iron deficiency may impact fetal growth and development by altering placental function. We used a rat model of diet-induced iron deficiency to investigate changes in placental growth and development. Pregnant Sprague-Dawley rats were fed either a low-iron or iron-replete diet starting 2 weeks before mating. Compared with controls, both maternal and fetal hemoglobin were reduced in dams fed low-iron diet

SUBMITTER: Roberts H 

PROVIDER: S-EPMC8559528 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature