Transcriptomic and proteomic analysis of pyrethroid resistance in the CKR strain of Aedes aegypti.

ABSTRACT: Aedes aegypti is an important vector of human viral diseases. This mosquito is distributed globally and thrives in urban environments, making it a serious risk to human health. Pyrethroid insecticides have been the mainstay for control of adult A. aegypti for decades, but resistance has evolved, making control problematic in some areas. One major mechanism of pyrethroid resistance is detoxification by cytochrome P450 monooxygenases (CYPs), commonly associated with the overexpression of one or more CYPs. Unfortunately, the molecular basis underlying this mechanism remains unknown. We used a combination of RNA-seq and proteomic analysis to evaluate the molecular basis of pyrethroid resistance in the highly resistant CKR strain of A. aegypti. The CKR strain has the resistance mechanisms from

SUBMITTER: Sun H 

PROVIDER: S-EPMC8559961 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature