Regionally specific gray matter volume is lower in alcohol use disorder: Implications for noninvasive brain stimulation treatment.

ABSTRACT:

Background

There is growing interest in neuromodulation-based therapeutics as tools for individuals with alcohol use disorder (AUD). Through electromagnetic induction, techniques such as transcranial magnetic stimulation (TMS) can noninvasively depolarize cortical cells in the induced electrical field and monosynaptic afferents. The ability of TMS to modulate the brain is dependent upon two factors, which may be compromised in individuals with AUD: (1) gray matter volume (GMV) at the site of stimulation and (2) scalp-to-cortex (STC) distance. This study tested the hypotheses that these aspects of neural architecture are compromised in AUD patients, and thus AUD patients may need a higher TMS dose to depolarize the cortex.

Methods

High-resolution magnetic resonance images wer

SUBMITTER: McCalley DM 

PROVIDER: S-EPMC8560006 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature