Modeling bystander effects that cause growth delay of breast cancer xenografts in bone marrow of mice treated with radium-223.

ABSTRACT:

Rationale

The role of radiation-induced bystander effects in cancer therapy with alpha-particle emitting radiopharmaceuticals remains unclear. With renewed interest in using alpha-particle emitters to sterilize disseminated tumor cells, micrometastases, and tumors, a better understanding of the direct effects of alpha particles and the contribution of the bystander responses they induce is needed to refine dosimetric models that help predict clinical benefit. Accordingly, this work models and quantifies the relative importance of direct effects (DE) and bystander effects (BE) in the growth delay of human breast cancer xenografts observed previously in the tibiae of mice treated with ²²³RaCl₂.

Methods

A computational model of MDA-MB-231 and MCF-7 human b

SUBMITTER: Rajon DA 

PROVIDER: S-EPMC8560015 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature