An 11-gene signature for the prediction of systemic recurrences in colon adenocarcinoma.

ABSTRACT:

Background

Prognosis varies among patients within the same colon adenocarcinoma (COAD) stage, indicating the need for reliable molecular markers to enable individualized treatment. This study aimed to investigate gene signatures that can be used for better prognostic prediction of COAD.

Methods

Gene-expression profiles of COAD patients were obtained from the Gene Expression Omnibus database (n = 332) and The Cancer Genome Atlas database (n = 431). The relationship between gene signature and relapse-free survival was analysed in the training set (n = 93) and validated in the internal validation set (n = 94) and external validation sets (n = 145 and 431).

Results

Overall, 11 genes (N-myc downstream re

SUBMITTER: Cai JW 

PROVIDER: S-EPMC8560041 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature