Aldosterone Blockade in Acute Myocardial Infarction: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

A comprehensive evaluation of the benefits of mineralocorticoid receptor antagonists (MRA) in acute myocardial infarction (AMI) patients is lacking.

Objective

To summarize the evidence on the efficacy and safety of MRA in patients admitted for AMI.

Methods

Articles were identified through PubMed, Embase, Cochrane Library, Ovid (Medline1946-2021), and ClinicalTrials.gov databases from their inception to December 31, 2020.

Results

15 articles with a total of 11,861 patients were included. MRA reduced the risk of all-cause mortality by 16% (relative ratio (RR): 0.84; 95% confidence interval (CI) (0.76, 0.94); P = 0.002) and the incidence of cardiovascular adverse events by 12% (RR: 0.88, 95% CI (0.83, 0.93), P < 0.00001) in post-AMI patien

SUBMITTER: Chen Q 

PROVIDER: S-EPMC8560277 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature