Comparison of metabolic effects of the progestational androgens dimethandrolone undecanoate and 11β-MNTDC in healthy men.

ABSTRACT:

Background

Dimethandrolone (DMA) and 11β-methyl-19-nortestosterone (11β-MNT) are two novel compounds with both androgenic and progestational activity that are under investigation as potential male hormonal contraceptives. Their metabolic effects have never been compared in men.

Objective

Assess for changes in insulin sensitivity and adiponectin and compare the metabolic effects of these two novel androgens.

Materials/methods

In two clinical trials of DMA undecanoate (DMAU) and 11β-MNT dodecylcarbonate (11β-MNTDC), oral prodrugs of DMA and 11β-MNT, healthy men received drug, or placebo for 28 days. Insulin and adiponectin assays were performed on stored samples. Mixed model analyses were performed to compare the effects of the two drugs. Student's t test, or the non-pa

SUBMITTER: Yuen F 

PROVIDER: S-EPMC8560544 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature