Institutional variation in survival and morbidity in laparoscopic surgery for colon cancer: From the data of a randomized controlled trial comparing open and laparoscopic surgery (JCOG0404).

ABSTRACT:

Background

Institutional variation in outcomes is a key factor to ascertain the generalizability of results and reliability of the clinical trial. This study evaluated institutional variation in survival and postoperative complications using data from JCOG0404 comparing laparoscopic colectomy (LAP) with open colectomy (OP).

Methods

Institutions with fewer than 10 registered patients were excluded from this analysis. Institutional variation was evaluated in terms of early postoperative complications, overall survival, and relapse-free survival and estimated using a mixed-effect model with institution as a random effect after adjusting for background factors.

Results

This analysis included 1028 patients in the safety analysis and 1040 patients in the efficacy analysis f

SUBMITTER: Katayama H 

PROVIDER: S-EPMC8560602 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature