Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype.

ABSTRACT:

Introduction

There is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population.

Methods

Based on the Washington Heights-Inwood Columbia Aging Project (WHICAP), LS7 scores were estimated to assess cardiovascular health status. Associations between LS7 scores and incident dementia were investigated by Cox proportional hazards models.

Results

Among 1987 subjects, 291 incident cases of dementia were identified over a median follow-up of 5.84 years. Compared with subjects in the poor cardiovascular health group (scores 0 to 5), those in intermediate (6 to 9) and optimal (10 to 14) groups had lower dementia risk, with the hazard ratio (HR; 95% confidence interval) being 0.74 (0.54 to 1.00) and 0.59 (0.38 to 0

SUBMITTER: Guo J 

PROVIDER: S-EPMC8560654 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature