Patient-Reported Outcomes-Guided Adaptive Radiation Therapy for Head and Neck Cancer.

ABSTRACT:

Purpose

To identify which patient-reported outcomes (PROs) may be most improved through adaptive radiation therapy (ART) with the goal of reducing toxicity incidence among head and neck cancer patients.

Methods

One hundred fifty-five head and neck cancer patients receiving radical VMAT (chemo)radiotherapy (66-70 Gy in 30-35 fractions) completed the MD Anderson Symptom Inventory, MD Anderson Dysphagia Inventory (MDADI), and Xerostomia Questionnaire while attending routine follow-up clinics between June-October 2019. Hierarchical clustering characterized symptom endorsement. Conventional statistical approaches indicated associations between dose and commonly reported symptoms. These associations, and the potential benefit of interfractional dose corrections, were further explo

SUBMITTER: Weppler S 

PROVIDER: S-EPMC8560706 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature