Cascade health service use in family members following genetic testing in children: a scoping literature review.

ABSTRACT: Cascade genetic testing is the identification of individuals at risk for a hereditary condition by genetic testing in relatives of people known to possess particular genetic variants. Cascade testing has health system implications, however cascade costs and health effects are not considered in health technology assessments (HTAs) that focus on costs and health consequences in individual patients. Cascade health service use must be better understood to be incorporated in HTA of emerging genetic tests for children. The purpose of this review was to characterise published research related to patterns and costs of cascade health service use by relatives of children with any condition diagnosed through genetic testing. To this end, a scoping literature review was conducted. Citation databases w

SUBMITTER: Cernat A 

PROVIDER: S-EPMC8560854 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature