Within patient genetic diversity of bla_KPC harboring Klebsiella pneumoniae in a Colombian hospital and identification of a new NTE_KPC platform.

ABSTRACT: Resistance to carbapenems in Klebsiella pneumoniae has been mostly related with the worldwide dissemination of KPC, largely due to the pandemic clones belonging to the complex clonal (CC) 258. To unravel bla_KPC post-endemic clinical impact, here we describe clinical characteristics of 68 patients from a high complexity hospital, and the molecular and genetic characteristics of their 139 bla_KPC-K. pneumoniae (KPC-Kp) isolates. Of the 26 patients that presented relapses or reinfections, 16 had changes in the resistance profiles of the isolates recovered from the recurrent episodes. In respect to the genetic diversity of KPC-Kp isolates, PFGE revealed 45 different clonal complexes (CC). MLST for 12 representative clones showed ST258 was present in the most frequent CC (2

SUBMITTER: Abril D 

PROVIDER: S-EPMC8560879 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature