Screening and Prognostic Analysis of Immune-Related Genes in Pancreatic Cancer.

ABSTRACT: Pancreatic cancer remains to have a high mortality, which is partly due to the lack of effective treatment strategies. In this study, genes with potential associations with immunophenotyping of pancreatic cancer were screened through bioinformatics analysis and the correlation between immune-related genes and the prognosis of pancreatic cancer patients was assessed. Firstly, differentially expressed immune genes were extracted from the pancreatic cancer-related datasets obtained for purposes of this study. The samples were processed by the "Consensus Cluster Plus" R package to determine the number of immune subtypes. Then, the pancreatic cancer immunophenotyping-related gene modules were determined. Differential analysis of immune gene modules was performed, and the function of genes relat

SUBMITTER: Wu X 

PROVIDER: S-EPMC8560963 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature