Investigation of Prognostic Markers of Lung Adenocarcinoma Based on Tumor Metabolism-Related Genes.

ABSTRACT: Lung adenocarcinoma (LUAD) is a prevalent cancer killer. Investigation on potential prognostic markers of LUAD is crucial for a patient's postoperative planning. LUAD-associated datasets were acquired from Gene Expression Omnibus (GEO) as well as The Cancer Genome Atlas (TCGA). LUAD metabolism-associated differentially expressed genes were obtained, combining tumor metabolism-associated genes. COX regression analyses were conducted to build a five-gene prognostic model. Samples were divided into high- and low-risk groups by the established model. Survival analysis displayed favorable prognosis in the low-risk group in the training set. Favorable predictive performance of the model was discovered as hinted by receiver's operative curve (ROC). Survival analysis and ROC analysis in the valida

SUBMITTER: Zhang C 

PROVIDER: S-EPMC8560970 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature