Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers.

ABSTRACT:

Objective

The aims of this study were to investigate the expression of Yes-associated protein 1 (YAP1), its prognostic significance, and the correlation between YAP1 and telomerase in various cancers.

Methods

The Gene Expression Profiling Interactive Analysis database was used to analyze RNA sequencing data and the survival rate of patients with various cancers in The Cancer Genome Atlas (TCGA) database. PrognoScan was used to analyze the prognostic value of YAP1 expression in various cancers. Tumor Immune Estimation Resource was used to determine the correlation between YAP1 expression and telomerase in various cancer types based on TCGA data.

Results

The analysis suggested that YAP1 was differentially expressed between tissues of various cancers and non-tumor tissue

SUBMITTER: Kim HR 

PROVIDER: S-EPMC8561022 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature