Prostaglandin E₂ directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF-β signalling.

ABSTRACT: Regulatory T (Treg) cells are essential for control of inflammatory processes by suppressing effector T-cell functions. The actions of PGE₂ on the development and function of Treg cells, particularly under inflammatory conditions, are debated. In this study, we employed pharmacological and genetic approaches to examine whether PGE₂  had a direct action on T cells to modulate de novo differentiation of Treg cells. We found that TGF-β-induced Foxp3 expression and iTreg cell differentiation in vitro is markedly inhibited by PGE₂ , which was mediated by the receptors EP2 and EP4. Mechanistically, PGE₂ -EP2/EP4 signalling interrupts TGF-β signalling during iTreg differentiation. Moreover, EP4 deficiency in T cells impaired iTreg cell differentiation i

SUBMITTER: Goepp M 

PROVIDER: S-EPMC8561111 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature