Reliability of Trial Information Across Registries for Trials With Multiple Registrations: A Systematic Review.

ABSTRACT:

Importance

Clinical trial registries are important for gaining an overview of ongoing research efforts and for deterring and identifying publication bias and selective outcome reporting. The reliability of the information in trial registries is uncertain.

Objective

To assess the reliability of information across registries for trials with multiple registrations.

Evidence review

For this systematic review, 360 protocols of randomized clinical trials (RCTs) approved by research ethics committees in Switzerland, the UK, Canada, and Germany in 2012 were evaluated. Clinical trial registries were searched from March to September 2019 for corresponding registrations of these RCTs. For RCTS that were recorded in more than 1 clinical trial registry, key trial characteristics t

SUBMITTER: Speich B 

PROVIDER: S-EPMC8561329 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature