Continental-scale genomic analysis suggests shared post-admixture adaptation in the Americas.

ABSTRACT: American populations are one of the most interesting examples of recently admixed groups, where ancestral components from three major continental human groups (Africans, Eurasians and Native Americans) have admixed within the last 15 generations. Recently, several genetic surveys focusing on thousands of individuals shed light on the geography, chronology and relevance of these events. However, even though gene flow could drive adaptive evolution, it is unclear whether and how natural selection acted on the resulting genetic variation in the Americas. In this study, we analysed the patterns of local ancestry of genomic fragments in genome-wide data for ~ 6000 admixed individuals from 10 American countries. In doing so, we identified regions characterized by a divergent ancestry profile (DA

SUBMITTER: Ongaro L 

PROVIDER: S-EPMC8561420 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature