Association of White Matter Hyperintensities With Pathology and Progression of Parkinsonism in Aging.

ABSTRACT:

Importance

Progressive parkinsonism is common in older adults without a diagnosis of Parkinson disease and is associated with adverse health outcomes, but its pathologic basis is controversial.

Objective

To examine if the burden of cerebral white matter hyperintensity (WMH), a common manifestation of cerebrovascular disease pathologies, is associated with the rate of progressive parkinsonism.

Design, setting, and participants

This community-based cohort study included participants recruited in 3 ongoing cohorts that began enrollment in 1994, 1997, and 2004. Prior to death, participants were observed for a mean of 7.5 years, with annual clinical assessments. From 4427 participants enrolled in the 3 cohorts, 2134 died. Postmortem autopsy was performed in 1725 decedents,

SUBMITTER: Oveisgharan S 

PROVIDER: S-EPMC8561430 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature