Association of Prior SARS-CoV-2 Infection With Risk of Breakthrough Infection Following mRNA Vaccination in Qatar.

ABSTRACT:

Importance

The effect of prior SARS-CoV-2 infection on vaccine protection remains poorly understood.

Objective

To assess protection from SARS-CoV-2 breakthrough infection after mRNA vaccination among persons with vs without prior SARS-CoV-2 infection.

Design, setting, and participants

Matched-cohort studies in Qatar for the BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) vaccines. A total of 1 531 736 individuals vaccinated with either vaccine between December 21, 2020, and September 19, 2021, were followed up beginning 14 days after receiving the second dose until September 19, 2021.

Exposures

Prior SARS-CoV-2 infection and COVID-19 vaccination.

Main outcomes and measures

Incident SARS-CoV-2 infection, defined as a polymerase chain reaction (PCR)-pos

SUBMITTER: Abu-Raddad LJ 

PROVIDER: S-EPMC8561432 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature