Sex-specific peripheral and central responses to stress-induced depression and treatment in a mouse model.

ABSTRACT: Major depressive disorder affects ~20% of the world population and is characterized by strong sexual dimorphism with females being two to three times more likely to develop this disorder. Previously, we demonstrated that a combination therapy with dihydrocaffeic acid and malvidin-glucoside to synergistically target peripheral inflammation and stress-induced synaptic maladaptation in the brain was effective in alleviating chronic social defeat stress (CSDS)-induced depression-like phenotype in male mice. Here, we test the combination therapy in a female CSDS model for depression and compared sex-specific responses to stress in the periphery and the central nervous system. Similar to male mice, the combination treatment is also effective in promoting resilience against the CSDS-induced depre

SUBMITTER: Deonaraine KK 

PROVIDER: S-EPMC8561614 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature