DNA methylation profile in patients with indolent systemic mastocytosis.

ABSTRACT:

Background

Mastocytosis is a clinically heterogeneous, usually acquired disease of the mast cells with a survival time that depends on the onset of the disease and ranges from skin-limited to systemic disease, including indolent and more aggressive variants. The crucial element in pathogenesis is the presence of oncogenic KIT somatic mutation D816V. Further epigenetic alterations are responsible for regulating the expression of genes. It is essential to identify indicators of disease progression, and the specific clinical picture to establish an appropriate therapeutic strategy.

Objective

The aim of this study was to analyze the relation of mastocytosis symptoms and epigenetic changes, and to identify epigenetic predictors of the disease.

Methods

Global DNA methylatio

SUBMITTER: Gorska A 

PROVIDER: S-EPMC8561632 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature