Pigment epithelium-derived factor attenuates angiogenesis and collagen deposition in hypertrophic scars.

ABSTRACT: Scar forming wounds are often characterized by higher levels of vascularity than non-scarring wounds and normal skin, and inhibition of angiogenesis has been shown to inhibit scar formation in some model systems. The rabbit ear hypertrophic scar (HS) model has been widely used to study the mechanisms that underlie the development of HS as well as the effectiveness of various treatments. Although the rabbit ear HS model is well characterized in terms of scar formation, the rate and level of angiogenesis has not been investigated in this model, and the cause-effect relationship between angiogenesis and rabbit HSs has not been examined. In the current study, full-thickness excisional wounds were created on the ventral side of New Zealand White rabbit ears to induce HS formation, and the dynam

SUBMITTER: Ma D 

PROVIDER: S-EPMC8561719 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature