CYP51A1 polymorphism and voriconazole-associated hepatotoxicity in children undergoing hematopoietic cell transplant.
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ABSTRACT:
SUBMITTER: Takahashi T
PROVIDER: S-EPMC8561836 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
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<i>CYP51A1</i> polymorphism and voriconazole-associated hepatotoxicity in children undergoing hematopoietic cell transplant.
Takahashi Takuto T Smith Angela R AR Jacobson Pamala A PA Alharbi Abeer F AF Fisher James J Rubin Nathan T NT Kirstein Mark N MN
International journal of clinical pharmacology and therapeutics 20210601 6
Fungal <i>CYP51A</i> (14α-sterol demethylase) is the target of an azole antifungal, voriconazole (VCZ), which also partially inhibits human <i>CYP51A1</i>. Hepatotoxicity is a common adverse effect of azoles, which is reported to be caused by altered gene expressions secondary to cholesterol synthesis inhibition by azoles. This is a post-hoc analysis of a previously conducted phase 1 dose-finding study of prophylactic VCZ in 56 pediatric hematopoietic cell transplant recipients. We explored an a ...[more]
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