A systematic literature review of frequency of vaso-occlusive crises in sickle cell disease.

ABSTRACT:

Background and purpose

Sickle cell disease (SCD) is a collection of rare inherited blood disorders affecting approximately 100,000 people in the U.S. and 20-25 million people globally. Individuals with SCD experience recurrent episodes of severe and unpredictable pain that are caused by vaso-occlusive crises (VOCs), a hallmark of the disease. VOCs are the primary cause of hospitalization in SCD, result in missed workdays and school days, and decrease quality of life (QoL). Although VOCs cause significant burden in the lives of individuals with SCD, there is no synthesis on the frequency of VOCs in the real world. This systematic literature review sought to identify literature describing the frequency of VOCs experienced by individuals with SCD in real-world settings.

Methods

SUBMITTER: Zaidi AU 

PROVIDER: S-EPMC8561926 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature