Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis.

ABSTRACT:

Background

Tranexamic acid (TXA) reduces surgical bleeding and reduces death from bleeding after trauma and childbirth. However, its effects on thrombotic events and seizures are less clear. We conducted a systematic review and meta-analysis to examine the safety of TXA in bleeding patients.

Methods

For this systematic review and meta-analysis, we searched MEDLINE, EMBASE and the Cochrane Central Register of Controlled trials from inception until June 1, 2020. We included randomized trials comparing intravenous tranexamic acid and placebo or no intervention in bleeding patients. The primary outcomes were thrombotic events, venous thromboembolism, acute coronary syndrome, stroke and seizures. A meta-analysis was performed using a random effects model and meta-regression analy

SUBMITTER: Murao S 

PROVIDER: S-EPMC8561958 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature