Effect of long-term adjuvant temozolomide chemotherapy on primary glioblastoma patient survival.

ABSTRACT:

Objective

Glioblastoma multiforme (GBM) is the most common primary malignant central nervous system (CNS) tumor. The Stupp regimen is the standard treatment, although the optimal number of temozolomide (TMZ) treatment cycles remains controversial. We compared the effects of standard 6 cycles versus > 6 cycles of TMZ chemotherapy post-surgery with concurrent chemoradiotherapy on primary GBM patient survival.

Patients and methods

We performed a single center retrospective study of GBM patients that underwent total resection, concurrent chemoradiotherapy, and at least 6 cycles of adjuvant TMZ chemotherapy from June 2011 to August 2018. Patients were divided into 2 groups based on adjuvant TMZ treatment plan: Group A(n = 27): standard 6-cycle adjuvant TMZ therapy and Group B(n =

SUBMITTER: Huang B 

PROVIDER: S-EPMC8561964 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature