Dynamic changes of genomic methylation profiles at different growth stages in Chinese Tan sheep.

ABSTRACT:

Background

Tan sheep, an important local sheep breed in China, is famous for their fur quality. One-month-old Tan sheep have white, curly hair with beautiful flower spikes, commonly known as "nine bends", which has high economic value. However, the "nine bends" characteristic gradually disappears with age; consequently, the economic value of the Tan sheep decreases. Age-related changes in DNA methylation have been reported and may be responsible for age-induced changes in gene expression. Until now, no genome-wide surveys have been conducted to identify potential DNA methylation sites involved in different sheep growth stages. In this study we investigated the dynamic changes of genome-wide DNA methylation profiles in Tan sheep using DNA from skin and deep whole-genome bisulfite se

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8561971 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature