Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis.

ABSTRACT: Allergic rhinitis (AR) is the most common undiagnosed chronic condition in children. Moderate/severe AR symptoms significantly impair quality of life, and cause sleep disruption, absenteeism and decreased productivity. Additionally, untreated AR predisposes children to asthma and other chronic conditions. Although intranasal corticosteroids are the most effective pharmacologic treatment for AR, oral antihistamines are often preferred. First-generation antihistamines may be chosen to relieve AR symptoms as they are inexpensive and widely available; however, they cause sedative and cardiovascular negative effects due to poor receptor selectivity. Therefore, second-generation antihistamines were developed to reduce adverse effects while retaining efficacy. There are fewer clinical trials in c

SUBMITTER: Meltzer EO 

PROVIDER: S-EPMC8561980 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature