Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma.

ABSTRACT: Oncogene-targeted therapy with B-Raf proto-oncogene (BRAF) and mitogen-activated protein kinase kinase (MEK) inhibitors induces a high initial response rate in patients with BRAF^V600-mutated melanoma, with a median duration of response of approximately 1 year^1-3. Immunotherapy with antibodies to programmed death 1 (PD-1) produces lower response rates but with long response duration. Preclinical models suggest that combining BRAF and MEK inhibitors with PD-1 blockade therapy improves antitumor activity^4-6, which may provide additional treatment options for patients unlikely to have long-lasting responses to either mode of therapy alone. We enrolled 15 patients with BRAF^V600-mutated metastatic melanoma in a first-in-human clinical trial of dabrafen

SUBMITTER: Ribas A 

PROVIDER: S-EPMC8562134 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature