Exercise improves high-fat diet- and ovariectomy-induced insulin resistance in rats with altered hepatic fat regulation.

ABSTRACT: A high-fat diet (HFD) and loss of endogenous estrogens increases the risk for type 2 diabetes (T2D) and insulin resistance. Although exercise is known to prevent and manage insulin resistance, the cellular mechanisms remain largely unknown, especially in the context of a combined HFD and endogenous estrogen loss via ovariectomy (OVX). This study uses female Wistar rats to assess the effect of diet, endogenous estrogens, an exercise on insulin resistance, serum hormones, hepatic AMPK, hepatic regulators of fat metabolism, and expression of signaling molecules of the brain reward pathway. The combination of the HFD/OVX increased the homeostatic model assessment of insulin resistance (HOMA-IR), the glucose-insulin (G-I) index, and the serum adiponectin and leptin values, and exercise decrease

SUBMITTER: Jacobs AJ 

PROVIDER: S-EPMC8562195 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature