μ-Crystallin in Mouse Skeletal Muscle Promotes a Shift from Glycolytic toward Oxidative Metabolism.

ABSTRACT: μ-Crystallin, encoded by the CRYM gene, binds the thyroid hormones, T₃ and T₄. Because T₃ and T₄ are potent regulators of metabolism and gene expression, and CRYM levels in human skeletal muscle can vary widely, we investigated the effects of overexpression of Crym. We generated transgenic mice, Crym tg, that expressed Crym protein specifically in skeletal muscle at levels 2.6-147.5 fold higher than in controls. Muscular functions, Ca²⁺ transients, contractile force, fatigue, running on treadmills or wheels, were not significantly altered, although T₃ levels in tibialis anterior (TA) muscle were elevated ~190-fold and serum T₄ was decreased 1.2-fold. Serum T₃ and thyro

SUBMITTER: Kinney CJ 

PROVIDER: S-EPMC8562245 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature