Selection into shift work is influenced by educational attainment and body mass index: a Mendelian randomization study in the UK Biobank.

ABSTRACT:

Background

Shift work is associated with increased cardiometabolic disease risk. This observation may be partly explained by cardiometabolic risk factors having a role in the selection of individuals into or out of shift work. We performed Mendelian randomization (MR) analyses in the UK Biobank (UKB) to test this hypothesis.

Methods

We used genetic risk scores (GRS) to proxy nine cardiometabolic risk factors and diseases (including educational attainment, body mass index (BMI), smoking, and alcohol consumption), and tested associations of each GRS with self-reported frequency of current shift work among employed UKB participants of European ancestry (n = 190 573). We used summary-level MR sensitivity analyses to assess robustness of the identified effects, and we tested whet

SUBMITTER: Daghlas I 

PROVIDER: S-EPMC8562336 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature