Outcomes reported in randomised controlled trials of major depressive disorder in older adults: protocol for a methodological review.

ABSTRACT:

Introduction

Major depressive disorder (MDD or depression) is prevalent among adults aged 65 years and older. The effectiveness and safety of interventions used to treat depression is often assessed through randomised controlled trials (RCTs). However, heterogeneity in the selection, measurement and reporting of outcomes in RCTs renders comparisons between trial results, interpretability and generalisability of findings challenging. There is presently no core outcome set (COS) for use in RCTs that assess interventions for older adults with MDD. We will conduct a methodological review of the literature for outcomes reported in trials for adults 65 years and older with depression to assess the heterogeneity of outcome measures.

Methods and analysis

RCTs evaluating pharmacother

SUBMITTER: Rodrigues M 

PROVIDER: S-EPMC8562520 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature