Marek's disease virus prolongs survival of primary chicken B-cells by inducing a senescence-like phenotype.

ABSTRACT: Marek's disease virus (MDV) is an alphaherpesvirus that causes immunosuppression and deadly lymphoma in chickens. Lymphoid organs play a central role in MDV infection in animals. B-cells in the bursa of Fabricius facilitate high levels of MDV replication and contribute to dissemination at early stages of infection. Several studies investigated host responses in bursal tissue of MDV-infected chickens; however, the cellular responses specifically in bursal B-cells has never been investigated. We took advantage of our recently established in vitro infection system to decipher the cellular responses of bursal B-cells to infection with a very virulent MDV strain. Here, we demonstrate that MDV infection extends the survival of bursal B-cells in culture. Microarray analyses revealed that most cyt

SUBMITTER: Trapp-Fragnet L 

PROVIDER: S-EPMC8562793 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature