Amniotic fluid microRNA profiles in twin-twin transfusion syndrome with and without severe recipient cardiomyopathy.

ABSTRACT:

Background

Twin-twin transfusion syndrome presents many challenges for clinicians, and the optimal means of identifying pregnancies that will benefit most from intervention is controversial. There is currently no clinically available biomarker to detect twin-twin transfusion syndrome or to stratify cases based on the risk factors. microRNAs are small RNAs that regulate gene expression and are biomarkers for various disease processes, including adult and pediatric heart failure. To date, no studies have investigated amniotic fluid microRNAs as biomarkers for disease severity, specifically for severe recipient cardiomyopathy in twin-twin transfusion syndrome cases.

Objective

This study aimed to assess whether amniotic fluid microRNAs could be useful as biomarkers to identify p

SUBMITTER: Willner EC 

PROVIDER: S-EPMC8562927 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature