Age-related expansion and increased osteoclastogenic potential of myeloid-derived suppressor cells.

ABSTRACT: Aging is associated with excessive bone loss that is not counteracted with the development of new bone. However, the mechanisms underlying age-related bone loss are not completely clear. Myeloid-derived suppressor cells (MDSCs) are a population of heterogenous immature myeloid cells with immunosuppressive functions that are known to stimulate tumor-induced bone lysis. In this study, we investigated the association of MDSCs and age-related bone loss in mice. Our results shown that aging increased the accumulation of MDSCs in the bone marrow and spleen, while in the meantime potentiated the osteoclastogenic activity of the CD11b⁺Ly6C^hiLy6G⁺ monocytic subpopulation of MDSCs. In addition, CD11b⁺Ly6C^hiLy6G⁺ MDSCs from old mice ex

SUBMITTER: Li Z 

PROVIDER: S-EPMC8562937 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature