A systematic review and meta-analysis of medications for stimulant use disorders in patients with co-occurring opioid use disorders.

ABSTRACT:

Background

Stimulant (cocaine and/or methamphetamine) use has increased among people with opioid use disorder. We conducted a systematic review of medications for stimulant use disorders in this population.

Methods

We searched for randomized controlled trials in multiple databases through April 2019, and dual-screened studies using pre-specified inclusion criteria. Primary outcomes were abstinence defined as stimulant-negative urine screens for ≥3 consecutive weeks; overall use as the proportion of stimulant-negative urine specimens; and retention as the proportion of participants who completed treatment. We rated strength of evidence using established criteria and conducted meta-analyses of comparable interventions and outcomes.

Results

Thirty-four trials of 22 medic

SUBMITTER: Chan B 

PROVIDER: S-EPMC8562993 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature